Related Experiment Video
Updated: Jun 10, 2026
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
Quantitative assessment of perirectal tumor infiltration with dynamic contrast-enhanced multi-detector row CT in
Can-Hui Sun1, Shi-Ting Feng, Ping Xiao
1Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, China.
Objective:
To evaluate the efficacy of discriminant function analysis of perirectal tumor infiltration with dynamic contrast-enhanced 64-detector row CT in rectal cancer.
Materials And Methods:
Forty-nine patients with rectal cancer underwent dynamic contrast-enhanced CT. A total of 96 axial CT slices containing the tumors were evaluated. The 96 images were separated into two groups with or without perirectal tumor infiltration based on pathological findings. The discriminant function was set-up using CT density differences between the mass and the adjacent perirectal tissue within 5 mm from the mass at 20 and 40 s as independent variables. The results of the discriminant function analysis were compared to those of CT morphology and pathology.
Results:
CT morphological diagnosis was accurate on 71.9% (69/96) of the slices with 82.5% sensitivity and 64.3% specificity. Discriminant function analysis correctly identified 88.5% (85/96) of the slices with 85.0% sensitivity and 91.1% specificity. Overstaging occurred significantly more (P<0.05) on morphological analysis (20.8%, 20/96) than discriminant function analysis (5.2%, 5/96) of the CT slices.
Conclusions:
Discriminant function analysis of dynamic contrast-enhanced CT improves the diagnostic accuracy and specificity of perirectal tumor infiltration in rectal cancer.
