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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...

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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Using Raman spectroscopy in tablet moisture surface analysis: tablet surface markers.

Eman Atef1, Harsh Chauhan, Michelle Ceresia

  • 1Department of Pharmaceutical Sciences, School of Pharmacy-Boston, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Avenue, Boston, MA 02115, USA.

Journal of Pharmaceutical and Biomedical Analysis
|August 3, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a Raman spectroscopy method to monitor tablet surface hydration by tracking changes in alcohol functional groups. This technique offers a way to inspect and control tablet drying processes effectively.

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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

Area of Science:

  • Pharmaceutical Sciences
  • Analytical Chemistry
  • Materials Science

Background:

  • Tablet surface hydration can impact drug stability and dissolution.
  • Monitoring water content is crucial for quality control in tablet manufacturing.
  • Existing methods for moisture measurement may not provide specific information about water binding sites.

Purpose of the Study:

  • To develop and validate a Raman spectroscopy-based method for monitoring tablet surface hydration.
  • To investigate the binding of atmospheric water to alcohol functional groups (C-OH) on tablet surfaces.
  • To compare Raman spectroscopy measurements with traditional microbalance moisture analysis.

Main Methods:

  • Utilized generic oral dissolving loratadine tablets with high mannitol and lactose content.
  • Employed Raman spectroscopy to measure changes in the intensity of the alcohol C-OH stretching peak at 875.5 cm(-1).
  • Compared Raman data with direct moisture measurements obtained using a microbalance.

Main Results:

  • Raman peak intensity of C-OH groups decreased upon tablet hydration, indicating water adsorption.
  • The developed hydration assay showed a Gaussian distribution (mean 3.22+/-0.277) for the ratio of C-OH to loratadine C-Cl peak intensities.
  • Raman analysis revealed both tightly and loosely bound water on the tablet surface.

Conclusions:

  • Raman spectroscopy can effectively monitor water bound to alcohol functional groups on tablet surfaces.
  • This technique provides a valuable tool for inspecting and controlling tablet drying processes.
  • The method offers insights into the specific binding of water molecules within the tablet matrix.