Related Experiment Video

Updated: Jun 10, 2026

Knee Arthrocentesis in Adults
04:41

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Etiology of septic arthritis in children: an update for the new millennium

Timothy P Young1, Lee Maas, Andrea W Thorp

  • 1Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Loma Linda University Children's Hospital, Loma Linda, CA 92354, USA. tpyoung@llu.edu

Insights

Pediatric septic arthritis cases show hip and knee involvement is common. Methicillin-sensitive Staphylococcus aureus is the most frequent cause, but community-associated MRSA is also a concern.

Area of Science:

  • Pediatric infectious diseases
  • Orthopedic infections
  • Microbiology

Background:

  • Pediatric septic arthritis epidemiology has shifted post-vaccination. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly prevalent.
  • Understanding causative organisms and affected joints is crucial for timely diagnosis and treatment.

Purpose of the Study:

  • To describe causative organisms and joint involvement in pediatric septic arthritis.
  • To analyze trends in the post-Haemophilus influenzae type B and post-pneumococcal vaccine era, considering CA-MRSA.

Main Methods:

  • Retrospective chart review of children under 13 diagnosed with septic arthritis (2003-2007).
  • Analysis of synovial fluid Gram stain, synovial fluid culture, and blood culture results.
  • Definition of septic arthritis based on positive pathogen identification in any of these tests.

Main Results:

  • Thirteen cases of pediatric septic arthritis were identified, involving fifteen joints.
  • The hip was the most commonly affected joint (6/15), followed by the elbow (3/15).
  • Methicillin-sensitive Staphylococcus aureus (MSSA) was the most frequent pathogen (6/13), followed by CA-MRSA (2/13) and Streptococcus pneumoniae (2/13).

Conclusions:

  • Hip and knee joints remain key sites for pediatric septic arthritis.
  • Elbow involvement should also be considered in diagnosis.
  • Empiric antibiotic coverage should include CA-MRSA, MSSA, and Streptococcus pneumoniae.
Abstract

Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...