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Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits
Published on: June 2, 2019
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Nepafenac-assisted mydriasis in a rabbit model
Michael K Yoon1, Ayman Naseri, Travis Porco
1Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
Journal of Cataract and Refractive Surgery
|August 3, 2010
Summary
Nepafenac 0.10% demonstrated superior pupil dilation compared to flurbiprofen 0.03% and placebo in a rabbit model. This finding suggests nepafenac may be more effective for mydriasis during ophthalmic procedures.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Pupil dilation is crucial for ophthalmic surgeries.
- Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage intraoperative miosis.
Purpose of the Study:
- To compare the efficacy of nepafenac 0.10% versus flurbiprofen 0.03% and placebo in achieving and maintaining pupil dilation in a rabbit model.
Main Methods:
- Adult pigmented rabbits were randomized into three groups: placebo, flurbiprofen, and nepafenac.
- Cataract surgery (phacoemulsification) was performed by a masked surgeon.
- Pupil diameters were measured preoperatively and postoperatively.
Main Results:
- Nepafenac achieved significantly greater preoperative pupil dilation (11.5 mm) than placebo (10.2 mm) and flurbiprofen (9.9 mm).
- This enhanced dilation was maintained postoperatively, with nepafenac group pupils (9.4 mm) larger than placebo (7.9 mm) and flurbiprofen (8.5 mm).
Conclusions:
- Nepafenac 0.10% is more effective than placebo and flurbiprofen 0.03% in achieving and maintaining mydriasis in rabbits.
- These findings support nepafenac's potential utility in ophthalmic procedures requiring adequate pupil dilation.
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