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Bromoderma in a patient with migrating partial seizures in infancy

Shin Nabatame1, Yoshiaki Saito, Hiroshi Sakuma

  • 1Department of Child Neurology, National Center Hospital (NCH), National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan.

Epilepsy Research
|August 3, 2010
PubMed

Insights

Potassium bromide (KBr) therapy for intractable childhood epilepsy can cause bromoderma, a skin condition. This case highlights the importance of recognizing this adverse effect, especially with prolonged KBr use.

Area of Science:

  • Dermatology
  • Pediatric Neurology

Background:

  • Intractable childhood epilepsy often requires specialized treatment.
  • Potassium bromide (KBr) is increasingly used for refractory epilepsy cases in children.

Observation:

  • A 5-month-old infant developed skin lesions after starting potassium bromide therapy.
  • Erythematous pustules evolved into vegetant plaques at sites of skin contact (EEG electrodes, nasogastric tube).
  • The bromoderma worsened at the biopsy site even after KBr cessation.

Findings:

  • Acquired bromoderma occurred 4 weeks into potassium bromide (KBr) treatment.
  • The condition presented as pustules and plaques, aggravated by skin trauma.
  • Delayed resolution of bromoderma was observed post-KBr discontinuation.

Implications:

  • Bromoderma tuberosum is a significant adverse effect of potassium bromide therapy.
  • Clinicians should be vigilant for skin manifestations in children treated with KBr.
  • Increased recognition of bromoderma is crucial given the rising use of KBr in pediatric epilepsy management.

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