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Bromoderma in a patient with migrating partial seizures in infancy.
Shin Nabatame1, Yoshiaki Saito, Hiroshi Sakuma
1Department of Child Neurology, National Center Hospital (NCH), National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan.
Epilepsy Research
|August 3, 2010
Summary
Potassium bromide (KBr) therapy for intractable childhood epilepsy can cause bromoderma, a skin condition. This case highlights the importance of recognizing this adverse effect, especially with prolonged KBr use.
Area of Science:
- Dermatology
- Pediatric Neurology
Background:
- Intractable childhood epilepsy often requires specialized treatment.
- Potassium bromide (KBr) is increasingly used for refractory epilepsy cases in children.
Observation:
- A 5-month-old infant developed skin lesions after starting potassium bromide therapy.
- Erythematous pustules evolved into vegetant plaques at sites of skin contact (EEG electrodes, nasogastric tube).
- The bromoderma worsened at the biopsy site even after KBr cessation.
Findings:
- Acquired bromoderma occurred 4 weeks into potassium bromide (KBr) treatment.
- The condition presented as pustules and plaques, aggravated by skin trauma.
- Delayed resolution of bromoderma was observed post-KBr discontinuation.
Implications:
- Bromoderma tuberosum is a significant adverse effect of potassium bromide therapy.
- Clinicians should be vigilant for skin manifestations in children treated with KBr.
- Increased recognition of bromoderma is crucial given the rising use of KBr in pediatric epilepsy management.
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