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Updated: Jun 10, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

The quest to identify heterogeneously resistant vancomycin-intermediate Staphylococcus aureus strains.

Fred C Tenover¹

¹Cepheid, 904 Caribbean Drive, Sunnyvale, CA 94089, USA. fred.tenover@cepheid.com

International Journal of Antimicrobial Agents

|August 3, 2010

Summary

Accurately identifying heterogeneously resistant vancomycin-intermediate Staphylococcus aureus (hVISA) in clinical labs remains challenging. New methods are needed to optimize treatment for serious Staphylococcus aureus infections.

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Last Updated: Jun 10, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

Clinical Microbiology
Infectious Diseases
Antimicrobial Resistance

Background:

Accurate identification of heterogeneously resistant vancomycin-intermediate Staphylococcus aureus (hVISA) is crucial for effective patient treatment.
hVISA infections, particularly infective endocarditis, require optimized antistaphylococcal therapy due to high bacterial loads.

Purpose of the Study:

To highlight the ongoing challenge in definitively identifying hVISA strains within routine clinical microbiology laboratories.
To underscore the clinical significance of hVISA detection for guiding patient therapy.

Main Methods:

The population analysis profile-area under the curve (PAP-AUC) method is accurate but not practical for routine clinical use.
Current alternative methods for hVISA identification often suffer from insufficient sensitivity and/or specificity.

Main Results:

Definitive identification of hVISA in clinical microbiology settings remains an unmet need.
Existing diagnostic approaches lack the required accuracy, sensitivity, or practicality for widespread adoption.

Conclusions:

The development of reliable and routine methods for hVISA detection is essential.
Continued research is necessary to address the diagnostic gap and improve patient outcomes for hVISA infections.