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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
What are Membranes?01:24

What are Membranes?

A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries markers that...
Membrane Carbohydrates01:30

Membrane Carbohydrates

The plasma membrane is a dynamic barrier composed of lipids, proteins, and carbohydrates. It is the epicenter of many cellular processes required for cell growth and survival. Carbohydrates have unique structural and chemical properties that help the plasma membrane to carry out its functions effectively.
Membrane carbohydrates do not have any hydrophobic region and are exclusively located on the cell's outer surface. The addition of sugar molecules or glycosylation of proteins happens in...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

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Related Experiment Video

Updated: Jun 10, 2026

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
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A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

Red cell membrane and malaria.

X An1, N Mohandas

  • 1Red Cell Physiology Laboratory, New York Blood Center, 310 East 67(th) Street, New York, NY 10065, USA. XAn@NYBloodcenter.org

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|August 3, 2010
PubMed
Summary
This summary is machine-generated.

Malaria parasites alter red blood cells by exporting over 400 proteins, causing structural changes. Understanding these parasite-red cell interactions is key to finding new malaria treatment targets.

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Last Updated: Jun 10, 2026

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

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Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography
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Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Published on: August 5, 2021

Area of Science:

  • * Malariology and Parasitology
  • * Cell Biology and Biochemistry

Background:

  • * Malaria remains a critical global health issue, causing millions of infections and hundreds of thousands of deaths annually, primarily in young children.
  • * The intra-erythrocytic stage of the malaria parasite involves the export of over 400 parasite proteins into the host red blood cell.
  • * These exported proteins significantly alter the red blood cell's structure and function.

Purpose of the Study:

  • * To investigate the protein-protein interactions between malaria parasites and host red blood cells during the intra-erythrocytic cycle.
  • * To identify specific binding domains involved in these crucial interactions.
  • * To understand how these interactions contribute to the pathogenesis of malaria.

Main Methods:

  • * Analysis of protein export during the 48-hour intra-erythrocytic parasite life cycle.
  • * Identification and characterization of binding domains in both parasite and red blood cell proteins.
  • * Investigating the consequences of protein-protein interactions on red blood cell morphology and properties.

Main Results:

  • * Over 400 parasite proteins are exported into the red blood cell cytoplasm.
  • * Several parasite proteins interact with the red cell's membrane skeleton.
  • * These interactions lead to significant changes in red blood cell shape, rheology, and adhesion.

Conclusions:

  • * Parasite-red cell protein interactions are fundamental to the structural and functional alterations observed in malaria-infected red blood cells.
  • * These alterations are directly linked to severe clinical manifestations like malarial anemia and cerebral malaria.
  • * Further understanding of these interactions offers promising avenues for developing novel therapeutic targets for malaria treatment.