Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B
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Updated: Jun 10, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Joanna Pancewicz1, Oksana Kowalczuk, Lech Chyczewski
1Department of Clinical Molecular Biology, Medical University of Bialystok, Poland. joannapancewicz@yahoo.co.uk
Abstract:
The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.
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