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Structure-activity relationships of epoxides: induction of sister-chromatid exchanges in Chinese hamster V79 cells
W von der Hude1, S Carstensen, G Obe
1Institut für Allgemeine Genetik, Freie Universität Berlin, F.R.G.
Abstract:
Analysis of SCE frequencies in Chinese hamster V79 cells was used to investigate structure-activity relationships of epoxides in mammalian cells. For this purpose the SCE-inducing potency of 58 epoxides was determined. Of these, 16 failed to induce SCE in V79 cells. According to the substitution of the oxirane ring the results show general agreement with results obtained in the Ames test. Mono-substituted epoxides had the highest genotoxic potency compared to di- and tri-substituted epoxides. In detail, there are differences in genotoxic potency between bacteria and mammalian cells which can be explained by differences in the cellular uptake of the compounds and by detoxification reactions.