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Updated: Jun 10, 2026

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain
Oleg V Moskvin1, Marie-Alda Gilles-Gonzalez, Mark Gomelsky
1Department of Molecular Biology, University of Wyoming, Dept. 3944, 1000 E. University Ave., Laramie, WY 82071, USA.
Abstract:
The SCHIC domain of the B12-binding domain family present in the Rhodobacter sphaeroides AppA protein binds heme and senses oxygen. Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA.
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