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Rotenone induces aneuploidy, polyploidy and endoreduplication in cultured Chinese hamster cells
1Institute of Environmental Toxicology, Tokyo, Japan.
Mutation Research
|July 1, 1991
Abstract:
The clastogenic potential of rotenone, an insecticide, was investigated in cultured Chinese hamster cells. Rotenone induced aneuploidy (hypodiploidy and hyperdiploidy), polyploidy, and endoreduplication, but not structural chromosome aberrations. The highest frequency of polyploidy and endoreduplication was 58.8% and 3.0%, respectively, when cells were treated with rotenone at 1.0 microgram/ml for 30 h.