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Insights into the phylogeny or arylamine N-acetyltransferases in fungi
Marta Martins1, Julien Dairou, Fernando Rodrigues-Lima
1Univ Paris Diderot-Paris 7, Unité de Biologie Fonctionnelle et Adaptative (BFA), CNRS EAC 4413, Laboratoire des Réponses Moléculaires et Cellulaires aux Xénobiotiques, 75013, Paris, France.
Abstract:
Previous studies have shown that Eumycetes fungi can acylate arylamine thanks to arylamine N-acetyltransferases, xenobiotic-metabolizing enzymes also found in animals and bacteria. In this article, we present the results of mining 96 available fungal genome sequences for arylamine N-acetyltransferase genes and propose their phylogeny. The filamentous Pezizomycotina are shown to possess many putative N-acetyltransferases, whilst these are often lacking in other fungal groups. The evolution of the N-acetyltransferases is best explained by the presence of at least one gene in the opisthokont ancestor of the fungi and animal kingdoms, followed by recurrent gene losses and gene duplications. A possible horizontal gene transfer event may have occurred from bacteria to the basidiomycetous yeast Malassezia globosa.
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