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Updated: Jun 10, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Autoimmune thyroiditis (Hashimoto's thyroiditis): current diagnostics and therapy]
1Medizinische Klinik, Asklepios Klinik Bad Oldesloe, Bad Oldesloe, Germany. h.fink@asklepios.com
Abstract:
Hashimoto's thyroiditis is a common autoimmune thyroid disease with preference of female gender. The chronic thyroiditis is characterized by autoantibodies against thyroid peroxidase and thyroglobulin. With manifestation, there is often a subclinical hypothyroidism that finally progresses to a persistent hypothyroidism with typical clinical symptoms and the need of hormonal substitution in succession of the lymphocytic infiltration of the thyroid. The ultrasound of the thyroid shows a hypoechogenic and inhomogeneous parenchyma. Autoimmune thyroiditis is frequently associated with autoimmune disease of other organs, such as vitiligo, Addison's disease, diabetes mellitus type 1, often in the sense of polyglandular syndrome 2.
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