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Updated: Jun 10, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Potentiating oncolytic viruses by targeted drug intervention
Douglas J Mahoney1, Dave F Stojdl
1Children's Hospital of Eastern Ontario Research Institute, Apoptosis Research Centre, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada.
Current Opinion in Molecular Therapeutics
|August 3, 2010
Summary
Oncolytic virus therapy (OVT) shows promise for cancer treatment. Combining OVT with chemotherapy or using advanced screening methods may enhance its effectiveness against heterogeneous cancers.
Area of Science:
- Oncology
- Virology
- Cancer Therapeutics
Background:
- Oncolytic virus therapy (OVT) utilizes tumor-specific defects for selective cancer cell targeting.
- Replicating viruses have shown efficacy in preclinical cancer models and are advancing into clinical trials.
- Cancer's inherent heterogeneity and genetic instability necessitate combination therapies for optimal outcomes.
Purpose of the Study:
- To review current strategies for augmenting oncolytic virus therapy (OVT).
- To discuss the combination of OVT with existing chemotherapies.
- To explore the potential of rationally designed chemical-OVT combinations and high-throughput screening.
Main Methods:
- Review of recent literature on OVT and combination therapies.
- Analysis of strategies combining OVT with chemotherapy.
- Evaluation of high-throughput genetic and chemical screening for OVT development.
Main Results:
- Significant efforts have focused on combining OVT with chemotherapy over the past five years.
- Rationally designed chemical-OVT combinations are being actively investigated.
- High-throughput screening technologies offer complementary advantages for discovering novel combinations.
Conclusions:
- Combination therapy is crucial for maximizing OVT efficacy in heterogeneous cancers.
- Integrating OVT with chemotherapy and employing advanced screening methods are key to developing effective cancer treatments.
- Future research should leverage unbiased screening to identify optimal chemical-OVT combinations.
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