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Texture-based classification of focal liver lesions on MRI at 3.0 Tesla: a feasibility study in cysts and hemangiomas
Marius E Mayerhoefer1, Wolfgang Schima, Siegfried Trattnig
1Department of Radiology, MR Center, Medical University of Vienna, Vienna, Austria. marius.mayerhoefer@meduniwien.ac.at
Purpose:
To determine the feasibility of texture analysis for the classification of liver cysts and hemangiomas, on nonenhanced, zero-fill interpolated T1- and T2-weighted MR images.
Materials And Methods:
Forty-five patients (26 women and 19 men; mean age, 58.1 +/- 16.9 years) with liver cysts or hemangiomas were enrolled in the study. After exclusion of images with artifacts, T1-weighted images of 42 patients, and T2-weighted images of 39 patients, obtained at 3.0 Tesla (T), were available for further analysis. Texture features derived from the gray-level histogram, co-occurrence and run-length matrix, gradient, autoregressive model, and wavelet transform were calculated. Fisher, probability of classification error and average correlation (POE+ACC), and mutual information coefficients were used to extract subsets of optimized texture features. Linear discriminant analysis (LDA) in combination with k nearest neighbor (k-NN) classification, and k-means clustering, were used for lesion classification.
Results:
LDA/k-NN produced misclassification rates of 16-18% on T1-weighted, and 12-18% on T2-weighted images. K-means clustering yielded misclassification rates of 15-23% on T1-weighted, and 15-25% on T2-weighted images.
Conclusion:
Texture-based classification of liver cysts and hemangiomas is feasible on zero-fill interpolated MR images obtained at 3.0T. Further studies are warranted to investigate the value of texture-based classification of other liver lesions, such as hepatocellular and cholangiocellular carcinoma, on MRI.
