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Updated: Jun 10, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
Nephrogenic systemic fibrosis: a review
Amy Y-Y Chen1, Matthew J Zirwas, Michael P Heffernan
1Wright State University Boonshoft School of Medicine, Department of Dermatology, Dayton, OH 45408, USA. ayyen@alum.mit.edu
Abstract:
Nephrogenic systemic fibrosis (NSF) is a recently described, debilitating systemic disease most commonly seen in patients with renal insufficiency. Exposure to gadolinium-containing contrast agent has been associated with the onset of symptoms. The epidemiology, pathogenesis, clinical manifestation, diagnosis, histolopathology, differential diagnosis and treatment will be reviewed. Clinicians should have a high index of suspicion in susceptible individuals.
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