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Updated: Jun 10, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Nonvalvular atrial fibrillation: thromboembolic risk assessment and therapy in a general practice population]
Francesco Del Zotti1, Giobatta Gottardi, Guglielmo Frapporti
1Divisione Clinicizzata di Cardiologia, A.O. Istituti Ospitalieri, Verona.
Insights
General practitioners in Italy appropriately prescribed antithrombotic therapy for atrial fibrillation (AF) in 34.4% of eligible patients. While comparable to other studies, further improvements in guideline adherence and coordination are needed for optimal stroke prevention.
Area of Science:
- Cardiology
- General Practice
- Pharmacotherapy
Context:
- Atrial fibrillation (AF) management relies heavily on general practitioners for antithrombotic therapy prescription.
- Assessing guideline adherence for antithrombotic therapy in non-valvular AF within primary care is crucial for stroke risk reduction.
Purpose:
- To evaluate the frequency and appropriateness of antithrombotic therapy in general practice for patients with non-valvular AF.
- To analyze prescription patterns based on thromboembolic risk factors using the CHADS2 score.
Summary:
- A study of 951 patients with non-valvular AF found 10.1% had contraindications to oral anticoagulants.
- Among the remaining 850 patients, 34.4% did not receive guideline-recommended antithrombotic therapy, with 12.0% receiving no treatment.
- Prescription rates were comparable to, or slightly better than, published data but indicate room for improvement.
Impact:
- Findings highlight the need for enhanced educational interventions for general practitioners regarding AF antithrombotic guidelines.
- Improved collaboration between cardiologists and general practitioners is essential for optimizing stroke prevention in AF patients.
- The study provides insights into current antithrombotic prescribing practices in Italian general practices, informing future quality improvement initiatives.
Background:
Cardiologists may prescribe antithrombotic therapy to patients with atrial fibrillation (AF), but prescription application mostly depends on general practitioners. The present study aims to assess frequency and appropriateness of antithrombotic therapy in general practice, as a function of thromboembolic risk factors, using the CHADS2 score.
Methods:
The computer records of 39 general practitioners were evaluated in order to identify patients with non-valvular AF; therapy and thromboembolic risk factors were recorded.
Results:
AF was documented in 951 patients; 96 (10.1%) had contraindications to oral anticoagulants. Among the remaining 850 patients, 292 (34.4%) did not receive antithrombotic therapy according to guidelines. In particular, 102 (12.0%) did not receive any antithrombotic treatment.
Conclusions:
Among general practitioners of the Veneto region (Italy), the application of guidelines on antithrombotic therapy in non-valvular AF is comparable, or even slightly better than that reported in published cohort studies, but it deserves further improvement. There is a need for targeted educational interventions and a better coordination between cardiologists and general practitioners.
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