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Study of fibrinogen in patients with diabetes mellitus

D R Kafle1, P Shrestha

  • 1Care Hospital, New Baneshwor, Kathmandu, Nepal. kafledilli@yahoo.com

Nepal Medical College Journal : NMCJ
|August 4, 2010
PubMed

Insights

Patients with diabetes mellitus face a higher cardiovascular disease risk. Elevated fibrinogen levels, a key risk factor, were significantly higher in diabetic patients, especially those with coronary artery disease.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Diabetes mellitus significantly increases cardiovascular disease (CVD) risk.
  • Traditional CVD risk factors do not fully explain this elevated risk in diabetic patients.
  • Fibrinogen is an independent CVD risk factor and is linked to traditional risk factors.

Purpose of the Study:

  • To investigate fibrinogen levels in patients with diabetes mellitus.
  • To compare fibrinogen levels between diabetic patients with and without coronary artery disease (CAD).

Main Methods:

  • A descriptive, analytical, cross-sectional study conducted at Tribhuvan University Teaching Hospital.
  • 120 patients were enrolled: 30 with diabetes, 30 with diabetes and CAD, 30 with CAD only, and 30 controls.
  • Fibrinogen levels were measured and compared across groups.

Main Results:

  • Fibrinogen levels were significantly higher in diabetic patients compared to controls.
  • Diabetic patients with CAD exhibited significantly higher fibrinogen levels than those with diabetes alone or CAD alone (p<0.01).

Conclusions:

  • Fibrinogen is elevated in diabetic patients.
  • Elevated fibrinogen is particularly pronounced in diabetic patients with co-existing coronary artery disease, suggesting its role in diabetes-associated CVD.

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