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Updated: Jun 10, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Systemic sclerosis--pathogenesis, clinical manifestations and treatment]
Mislav Radić1, Dusanka Martinović Kaliterna, Damir Fabijanić
1Klinika za unutarnje bolesti, Kliniki bolnicki centar Split. mislavradic@gmail.com
Lijecnicki Vjesnik
|August 4, 2010
Summary
Diffuse systemic sclerosis (SSc) is a chronic autoimmune disease causing fibrosis and vascular issues. Current treatments manage symptoms, as no cure significantly alters its overall progression.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Context:
- Diffuse systemic sclerosis (SSc) is a chronic, multisystem autoimmune disease.
- Characterized by widespread fibrosis and vascular abnormalities affecting skin and internal organs.
- Pathogenesis involves complex immunologic mechanisms, vascular damage, and fibroblast activation.
Purpose:
- To review the current understanding of systemic sclerosis pathogenesis.
- To outline the diverse clinical manifestations of SSc.
- To discuss current therapeutic strategies for managing SSc symptoms and organ involvement.
Summary:
- Systemic sclerosis involves immune dysregulation, vascular injury, and fibroblast overactivity, leading to organ fibrosis.
- Clinical presentation varies widely, with visceral complications being a major cause of mortality.
- While no drug modifies the overall disease course, symptomatic and organ-specific treatments offer patient benefit.
Impact:
- Highlights the need for further research into SSc pathogenesis to identify disease-modifying therapies.
- Emphasizes the importance of early diagnosis and multidisciplinary management for improving patient outcomes.
- Provides a comprehensive overview for clinicians managing patients with systemic sclerosis.
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