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Related Concept Videos

Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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Related Experiment Video

Updated: Jun 10, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

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Published on: March 17, 2008

Development of a sustained fluoride delivery system.

Olga Baturina1, Eser Tufekci, Ozge Guney-Altay

  • 1Naval Research Laboratories, Alexandria, VA, USA.

The Angle Orthodontist
|August 4, 2010
PubMed
Summary
This summary is machine-generated.

This study developed a novel fluoride delivery system using coated elastomeric rings for controlled fluoride release. The new matrix successfully released fluoride at therapeutic levels, preventing initial burst release.

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Dental Materials

Background:

  • Orthodontic treatment often involves elastomeric ligatures.
  • Controlled fluoride release from orthodontic materials can prevent demineralization.
  • Existing delivery systems may lack consistent therapeutic profiles.

Purpose of the Study:

  • To engineer a novel elastomeric ring system for sustained fluoride ion delivery.
  • To investigate the fluoride release kinetics from a modified polyethylene co-vinyl acetate (PEVA) matrix.
  • To assess the therapeutic efficacy of the developed fluoride-releasing orthodontic components.

Main Methods:

  • Sodium fluoride (NaF) was incorporated into PEVA elastomer samples.
  • A dip-coating technique was employed to create an overcoat on selected samples.
  • In vitro fluoride release was quantified over 45 days using an ion-selective electrode.

Main Results:

  • Coated samples with 0.4 g NaF achieved therapeutic fluoride release levels (0.7 microg F(-)/ring/d).
  • The dip-coating method controlled fluoride release, mitigating the initial burst effect.
  • Comparison of coated versus uncoated samples demonstrated a more consistent release profile with the coating.

Conclusions:

  • A novel fluoride delivery matrix was successfully developed using coated elastomeric rings.
  • The system demonstrated a therapeutically effective rate and profile for fluoride release.
  • This approach offers potential for enhanced caries prevention during orthodontic therapy.