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Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
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Published on: November 6, 2019

Pathogenesis of tinea.

Jochen Brasch1

  • 1Department of Dermatology, Venereology and Allergy, University Clinic of Schleswig-Holstein, Kiel, Germany. jbrasch@dermatology.uni-kiel.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|August 4, 2010
PubMed
Summary
This summary is machine-generated.

Dermatophyte infections, known as tinea, occur when these fungi invade keratinous tissues like skin and nails. Host immune responses and fungal factors determine infection severity and healing.

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Area of Science:

  • Mycology
  • Dermatology
  • Immunology

Background:

  • Dermatophytes are fungi that degrade keratin, leading to superficial skin infections called tinea.
  • Tinea pathogenesis involves fungal factors and host defense mechanisms.
  • Infections affect keratin-rich structures like skin, nails, and hair follicles.

Purpose of the Study:

  • To outline the pathogenesis of dermatophyte infections.
  • To describe the host's immune response to dermatophytes.
  • To highlight factors influencing tinea severity and unique challenges in nail infections.

Main Methods:

  • Review of dermatophyte infection processes.
  • Analysis of host-pathogen interactions.
  • Examination of immune responses in tinea.

Main Results:

  • Dermatophyte infection involves adherence, hyphal growth, enzyme release, and keratinocyte activation.
  • Host immune responses include innate and specific immunity (neutrophils, macrophages, antibodies, T cells).
  • Nail and hair follicle infections present unique challenges due to fungal accessibility and hormonal factors.

Conclusions:

  • Cellular immune mechanisms are critical for tinea healing.
  • Dermatophyte infections trigger complex inflammatory and immune reactions.
  • Understanding these mechanisms is key to managing tinea and associated conditions like id reactions.