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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

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Angiogenesis inhibitors in the treatment of prostate cancer

Clara Hwang1, Elisabeth I Heath

  • 1Department of Internal Medicine, Henry Ford Hospital, CFP 559, 2799 West Grand Blvd, Detroit, MI 48202, USA. chwang2@hfhs.org

Journal of Hematology & Oncology
|August 4, 2010
PubMed

Insights

Anti-angiogenic therapy, targeting new blood vessel formation, shows promise for prostate cancer treatment. Further phase III studies are crucial to determine the efficacy and role of these agents in castrate-resistant metastatic disease.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Prostate cancer, particularly castrate-resistant metastatic disease, presents limited therapeutic options.
  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and represents a therapeutic target.

Purpose of the Study:

  • To review the application of anti-angiogenic therapy in prostate cancer.
  • To discuss the efficacy and toxicity of various anti-angiogenic agents in this context.

Main Methods:

  • Literature review of anti-angiogenic agents in prostate cancer.
  • Analysis of efficacy and toxicity data from clinical studies.

Main Results:

  • Anti-angiogenic agents have shown success in other solid tumors.
  • Efficacy and toxicity profiles of different anti-angiogenic classes in prostate cancer are under investigation.

Conclusions:

  • Anti-angiogenic therapy is a developing strategy for prostate cancer.
  • The ultimate role of these agents depends on ongoing phase III trial results.

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