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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

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Related Experiment Video

Updated: Jun 10, 2026

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
09:23

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Published on: June 30, 2019

Novel Mycobacterium tuberculosis complex pathogen, M. mungi.

Kathleen A Alexander1, Pete N Laver, Anita L Michel

  • 1Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. kathyalx@vt.edu

Emerging Infectious Diseases
|August 4, 2010
PubMed
Summary
This summary is machine-generated.

A novel Mycobacterium tuberculosis complex pathogen, M. mungi sp. nov., caused recent severe outbreaks in banded mongooses. Further research is needed to understand its host spectrum and transmission dynamics.

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Identification of Mycobacterium Species by DNA Microarray Chip Method
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Last Updated: Jun 10, 2026

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
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Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Published on: June 30, 2019

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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Identification of Mycobacterium Species by DNA Microarray Chip Method
06:27

Identification of Mycobacterium Species by DNA Microarray Chip Method

Published on: June 24, 2025

Area of Science:

  • Veterinary Microbiology
  • Wildlife Disease Ecology
  • Zoonotic Pathogen Research

Background:

  • Banded mongooses are experiencing recurrent, high-mortality outbreaks.
  • These outbreaks are increasing in frequency and troop involvement.
  • The causative agent of these mongoose disease outbreaks has not been previously identified.

Purpose of the Study:

  • To identify the pathogen responsible for recent banded mongoose outbreaks.
  • To characterize the identified pathogen within the Mycobacterium tuberculosis complex.
  • To establish a foundation for understanding mongoose disease dynamics.

Main Methods:

  • Pathogen isolation and identification from affected banded mongoose populations.
  • Genomic and phylogenetic analysis to classify the novel pathogen.
  • Field observations in Chobe District, Botswana, to document outbreaks.

Main Results:

  • A novel species, Mycobacterium mungi sp. nov., belonging to the Mycobacterium tuberculosis complex, was identified as the causative agent.
  • The pathogen was detected in banded mongooses living in close proximity to human settlements in Botswana.
  • The study documented seven distinct outbreaks with significant mortality.

Conclusions:

  • Mycobacterium mungi sp. nov. is the etiological agent of severe, recurrent disease in banded mongooses.
  • The proximity of infected mongoose populations to humans raises potential public health concerns.
  • Crucial aspects, including the full host range and transmission pathways of M. mungi, remain to be elucidated.