Related Experiment Video
Updated: Jun 10, 2026

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
Published on: November 14, 2025
Acute, reversible axonal energy failure during stroke-like episodes in MELAS
Michelle A Farrar1, Cindy S-Y Lin, Arun V Krishnan
1Neuroscience Research Australia, Barker Street, Randwick, Sydney, New South Wales 2031, Australia.
Abstract:
The pathophysiology of stroke-like episodes in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) remains unresolved. Possible mechanisms include mitochondrial angiopathy, cytopathy, or both, collectively resulting in cellular energy depletion. To clarify disease mechanisms, axonal excitability properties were investigated in a 10-year-old child with MELAS. Serial assessments during a stroke-like episode revealed reversible depolarization of the axonal membrane consistent with disruption of energy-dependent processes. Axonal parameters correlated with the clinical assessment of central dysfunction and biochemical measures of acidosis. Novel axonal excitability techniques have established acute, reversible ischemic-like depolarization that may serve as a surrogate marker of central events that develop during stroke-like episodes in MELAS.
Related Concept Videos
Transient Ischemic Attack l: Introduction
Ischemic Stroke ll: Pathophysiology
Secondary Spinal Cord Injury llI: Pathophysiology
Ischemic Stroke l: Introduction
Cytotoxic Edema: Pathophysiology
Stroke: Introduction and Types
