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Updated: Jun 10, 2026

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
11:33

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Published on: December 17, 2013

The EspF effector, a bacterial pathogen's Swiss army knife.

Ashleigh Holmes1, Sabrina Mühlen, Andrew J Roe

  • 1Faculty of Biomedical and Life Sciences, Microbiology Research Theme, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom.

Infection and Immunity
|August 4, 2010
PubMed
Summary

The bacterial effector EspF, crucial for pathogen virulence, exhibits diverse functions within host cells. This review details EspF

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Area of Science:

  • Microbiology
  • Cell Biology
  • Pathogenesis

Background:

  • Bacterial pathogens deliver effector proteins into host cells for pathogenesis.
  • EspF is a multifunctional effector protein from attaching and effacing pathogens like EPEC and EHEC.
  • EspF plays roles in disrupting host cell processes and immune evasion.

Purpose of the Study:

  • To review the diverse functions of the bacterial effector EspF within host cells.
  • To discuss recent findings and molecular insights into EspF's multifunctionality.
  • To highlight EspF's contribution to bacterial virulence.

Main Methods:

  • Literature review of recent studies on EspF.
  • Analysis of molecular mechanisms underlying EspF's functions.
  • Synthesis of current knowledge on EspF's role in pathogenesis.

Main Results:

  • EspF disrupts epithelial barriers, modulates cytoskeleton, and affects host cell organelles.
  • It inhibits host transporters, promotes cell invasion, and induces apoptosis.
  • EspF's small size belies its extensive range of activities.

Conclusions:

  • EspF is a highly versatile bacterial effector protein.
  • Understanding EspF's molecular activities provides insights into bacterial pathogenesis.
  • Further research into EspF can reveal novel therapeutic targets.