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Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
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Decrease in immunoglobulin free light chains in patients with rheumatoid arthritis upon rituximab (anti-CD20)

T Groot Kormelink1, J Tekstra, R M Thurlings

  • 1Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.

Annals of the Rheumatic Diseases
|August 4, 2010
PubMed
Summary
This summary is machine-generated.

Free light chains (FLCs) are elevated in rheumatoid arthritis (RA) joints and correlate with disease activity. FLC levels predict treatment response to rituximab, suggesting FLCs as potential therapeutic targets in RA.

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In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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Published on: May 4, 2017

Area of Science:

  • Immunology
  • Rheumatology

Background:

  • Immunoglobulin (Ig) free light chains (FLCs) are implicated in inflammation in experimental models.
  • FLCs are short-lived B cell products.

Purpose of the Study:

  • Investigate FLC concentrations in inflamed joints of rheumatoid arthritis (RA) patients compared to osteoarthritis patients.
  • Determine the relationship between FLCs and disease activity during B cell depletion therapy (rituximab) in RA patients.

Main Methods:

  • Analyzed synovial fluid (SF) and tissue from RA patients for local FLC presence using ELISA and immunohistochemistry.
  • Measured FLC concentrations at baseline, 3, and 6 months post-rituximab treatment in 50 RA patients.
  • Correlated FLC changes with disease activity and other immune markers (IgM, IgG, IgA, IgM-RF, IgG-ACPA).

Main Results:

  • FLCs were detected in RA synovial tissue and SF, correlating with serum FLC levels.
  • Serum FLC concentrations correlated significantly with disease activity scores (28-joint count, ESR, CRP).
  • Changes in FLCs correlated with clinical improvement after rituximab, distinguishing responders from non-responders.

Conclusions:

  • FLCs are abundant in inflamed RA joints and correlate with disease activity.
  • FLC levels may serve as predictive biomarkers for rituximab treatment response in RA.
  • Targeting FLCs could be a potential therapeutic strategy for RA.