Related Experiment Video
Updated: Jan 10, 2026
Disorders of Erythrocytes
Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC
Maaret Castrén1, Per Nordberg, Leif Svensson
1Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
Background:
Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine. The aim of this study was to determine the safety, feasibility, and cooling efficacy of prehospital transnasal cooling in humans and to explore its effects on neurologically intact survival to hospital discharge.
Methods And Results:
Witnessed cardiac arrest patients with a treatment interval
Conclusions:
Prehospital intra-arrest transnasal cooling is safe and feasible and is associated with a significant improvement in the time intervals required to cool patients.
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