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Premature coronary artery disease in a patient with glycogen storage disease III

Matthew LaBarbera1, Gary Milechman, Fiona Dulbecco

  • 1Department of Cardiology, California Pacific Medical Center, San Francisco, California 94115, USA.

The Journal of Invasive Cardiology
|August 4, 2010
PubMed

Insights

Glycogen storage disease type III (GSD III) may increase the risk of early heart problems. This case report highlights a young patient with GSD III experiencing a heart attack and cardiac arrest, suggesting a need for cardiac screening.

Area of Science:

  • Metabolic disorders
  • Cardiovascular medicine
  • Genetics

Background:

  • Glycogen storage disease type III (GSD III) is a rare inherited metabolic disorder impacting intracellular glycogen metabolism.
  • Existing research links GSD III to dyslipidemia and endothelial dysfunction.
  • Premature atherosclerotic heart disease in GSD III patients has not been previously documented.

Observation:

  • A 24-year-old patient diagnosed with GSD III presented with ventricular fibrillation cardiac arrest.
  • The cardiac arrest occurred in the context of an anterior wall myocardial infarction.

Findings:

  • This case represents the first reported instance of premature atherosclerotic heart disease in a patient with GSD III.
  • The patient's presentation underscores a potential link between GSD III and early-onset cardiovascular events.

Implications:

  • Further research is crucial to determine the prevalence of atherosclerotic heart disease in the GSD III population.
  • Developing screening protocols and preventative strategies for at-risk GSD III patients is essential.
  • This case highlights the importance of considering cardiovascular complications in patients with rare metabolic disorders.

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