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Synergistic dual automaticity in sinoatrial node cell and tissue models

Hong Zhang1, Boyoung Joung, Tetsuji Shinohara

  • 1Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Circulation Journal : Official Journal of the Japanese Circulation Society
|August 4, 2010
PubMed
Summary

Sarcoplasmic reticulum (SR) Ca(2+) cycling significantly impacts sinoatrial node (SAN) automaticity, modulating heart rate. Both SR Ca(2+) dynamics and membrane currents (I(f), I(CaL), I(CaT)) are crucial for rhythmic heartbeats.

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