Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cutting through stigma: psychiatry and neurosurgery working together.

The British journal of psychiatry : the journal of mental science·2026

Same author

DBS: from neuromodulation to neuroremodelling.

Nature neuroscience·2026

Same author

Quality of "on": a novel therapeutic objective in advanced Parkinson's disease.

Parkinsonism & related disorders·2026

Same author

Unilateral promise and bilateral caution in focused ultrasound for Parkinson's disease.

The Lancet. Neurology·2026

Same author

A prognostic human brain network for diffuse midline glioma.

Nature·2026

Same author

Waveform-Conversion to Salvage Failed Spinal Cord Stimulation: A Systematic Review of Current Evidence.

Neuromodulation : journal of the International Neuromodulation Society·2026

Same journal

Electric-Scooters: An Emerging Source of High-Severity Pediatric Head Trauma.

Neurosurgery·2026

Same journal

Survival After Surgery for Spinal Osteosarcoma and the Role of Chemotherapy and Treatment Sequencing: A National Cohort Multivariable Analysis.

Neurosurgery·2026

Same journal

Safety and Efficacy of 3-Month Versus 6-Month Duration of Dual Antiplatelet Therapy in Pipeline Embolization Treatment of Intracranial Aneurysms.

Neurosurgery·2026

Same journal

Risk Factors of Revision Surgery After Acute Proximal Junctional Fracture Following Adult Spinal Deformity Surgery.

Neurosurgery·2026

Same journal

Sensorimotor Network Alterations and Compensation in Cervical Spondylotic Myelopathy: A 7 T Task-Based and Resting-State Functional MRI Study.

Neurosurgery·2026

Same journal

Hyperselective Peripheral Neurectomy Versus Medical Therapy for Refractory Poststroke Spasticity: A Randomized Controlled Trial.

Neurosurgery·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation

Published on: February 27, 2026

Minimizing brain shift in stereotactic functional neurosurgery.

Erika A Petersen¹, Etienne M Holl, Irene Martinez-Torres

¹Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK.

|August 4, 2010

Summary

This summary is machine-generated.

Image-guided stereotactic functional neurosurgery resulted in minimal subcortical brain shift. This approach did not negatively impact clinical outcomes in deep brain stimulation (DBS) procedures for patients with Parkinson disease.

More Related Videos

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System

Published on: June 9, 2023

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation

Published on: February 27, 2026

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System

Published on: June 9, 2023

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Area of Science:

Neurosurgery
Medical Imaging
Neurological Disorders

Background:

Precise anatomical targeting is crucial for stereotactic functional neurosurgical interventions.
Deep brain stimulation (DBS) and lesioning require accurate electrode or lesion placement.
Subcortical brain shift has been a concern in stereotactic targeting.

Purpose of the Study:

To quantify subcortical brain shift during image-guided stereotactic functional neurosurgery.
To assess the impact of brain shift on clinical outcomes in DBS procedures.

Main Methods:

Recorded anterior and posterior commissural (AC and PC) coordinates from pre- and post-implantation stereotactic MRI in 136 procedures.
Calculated changes in AC-PC length and stereotactic coordinates.
Reviewed Unified Parkinson's Disease Rating Scale (UPDRS-III) scores for Parkinson's disease patients undergoing subthalamic nucleus (STN) DBS.

Main Results:

Mean change in AC-PC length was minimal (0.6 mm).
No significant differences in brain shift were observed across patient subgroups (age, sex, target, unilateral/bilateral).
Negligible correlation found between brain shift magnitude and motor improvement in STN DBS for Parkinson's disease.

Conclusions:

Image-guided stereotactic techniques significantly limit subcortical brain shift.
Observed brain shift did not adversely affect clinical outcomes in DBS procedures.
Current image-guided approaches enhance the safety and efficacy of functional neurosurgery.