Simultaneous Raman and elastic light scattering imaging for particle formation investigation

We used two-dimensional laser Raman scattering and elastic light scattering to analyze mixture driven particle formation in the supercritical antisolvent process. Using only one excitation laser, the partial density of the antisolvent CO(2), the composition of the solvent/antisolvent mixture, and the occurrence of particle formation can be analyzed simultaneously. Thus, all main parameters that influence the process of particle formation and, subsequently, the desired properties of the produced powder are accessible.