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A preliminary study of the ocular hypotensive effects of bromocriptine in diabetic patients with autonomic neuropathy
M R al-Sereiti1, P Turner, E A Gale
1Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
Postgraduate Medical Journal
|April 1, 1991
Abstract:
The effect of bromocriptine on intraocular pressure has been investigated in a group of 8 diabetic patients with autonomic neuropathy, to test the hypothesis that bromocriptine exerts its ocular hypotensive action through presynaptic dopamine receptors. Bromocriptine eye drops (0.025%) produced a significant fall in intraocular pressure in a control group of 8 matched normal volunteers, but this effect was not seen in the eyes of the diabetic patients. These results are consistent with a presynaptic site of action of bromocriptine.