Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and

Jianjun Bao1, Michael N Sack

  • 1Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, 10 Center Drive, MSC 1454, Bethesda, MD 20892-1454, USA.

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Regulation of the Unfolded Protein Response

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Translational Regulation

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Protein Modifications in the RER

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Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...