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Updated: Jun 10, 2026

Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging
Published on: December 22, 2020
Applications of MALDI-MSI to pharmaceutical research
Brendan Prideaux1, Dieter Staab, Markus Stoeckli
1Analytical Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Abstract:
MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections.
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