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Updated: Jun 10, 2026

Design of Solid-State Fermentation Systems for Polymer Hydrolytic Extracellular Enzyme Production by Filamentous Fungi
Published on: June 6, 2025
[Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus]
Ming Ruan1, Li-Yang Zhang, Bin Yu
1Institute of Medicinal Fungi, Department of Life Science, Nanjing Xiaozhuang University, Nanjing 211171, China.
Objective:
To study the transformation of Astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus var. mongholicus.
Methods:
The chemical components of pre and post-fermenting were comparatively analyzed by techniques of HPLC, column chromatography and spectral identification. Antioxidant effect of transformational product on vascular endothelial cells was researched.
Results:
In fermenting of Astragalus membranaceus, Astragaloside IV was transformed into 6-O-beta-D-glucoside cycloastragenol, which had significant antioxidant effect.
Conclusion:
Biotransformation of Astragaloside IV in Astragalus membranaceus was occurred after bidirectional solid fermenting with Ganoderma lucidum, and the biotransformation could enhance effect.
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