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[Protective and therapeutic effects of schisandrol A on Abeta damaged PC12 cells]
Fei Xiao1, Wen Weng, Huan-Min Luo
1Jinan University, School of Medicine, Guangzhou 510632, China.
Objectives:
To observe the protective and therapeutic effect of schisandrol A on the Abeta damaged PC12 cells.
Methods:
PC12 cells were damaged by Abeta in vitro. Morphological changes were observed and the number of cells with neurite was analyzed by phase contrast microscope. The cell viability of PC12 cells was determined by the MTT method.
Results:
Many dispirited cells with atrophied or fragmented neurites in the Abeta damaged PC12 cells were observed under the microscope. More vital cells with longer neurites were observed in the schisandrol A treated PC12 cells and the number of cells with neurite increased. The difference of cell viability between the two groups was statistical significant.
Conclusion:
Schisandrol A can antagonize the neurotoxicity of Abeta and has protective and therapeutic efficacy on Abeta damaged PC12 cells.
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