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Related Experiment Video

Updated: Jun 10, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

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Published on: November 10, 2017

Otoscopic findings in hypercholesterolemic subjects.

A Pirodda1, C Bruzzi, G G Ferri

  • 1Department of Specialist Surgical and Anaesthesiological Sciences, ENT Section, S.Orsola-Malpighi University Hospital, Bologna, Italy. antonio.pirodda@unibo.it

B-ENT
|August 5, 2010
PubMed
Summary

This study found a significant link between tympanosclerosis and atherosclerosis in hypercholesterolemic patients. Tympanic plaques were more common in those with lipid dysfunction, suggesting a preclinical connection.

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Last Updated: Jun 10, 2026

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09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiovascular Medicine
  • Otolaryngology

Background:

  • Tympanosclerosis, characterized by tympanic membrane plaques, is often considered clinically insignificant.
  • Atherosclerosis involves arterial plaque buildup, a risk factor for cardiovascular disease.

Purpose of the Study:

  • To investigate the relationship between tympanosclerosis and atherosclerosis.
  • To examine this link in individuals with lipid metabolism dysfunction but no overt atherosclerotic symptoms.

Main Methods:

  • 40 hypercholesterolemic patients underwent Doppler ultrasound of carotid and vertebrobasilar arteries.
  • Otoscopy was used to detect tympanic membrane sclerotic plaques.
  • A control group of 41 healthy subjects was included for comparison.

Main Results:

  • Tympanic sclerotic plaques were found in 22.5% of hypercholesterolemic patients versus 4.9% in controls (p=0.02).
  • A stronger association (p=0.01) was observed between tympanic plaques and arterial plaques detected via Doppler ultrasound.
  • 41.2% of patients with arterial plaques had tympanic plaques, compared to 8.7% without arterial plaques.

Conclusions:

  • The study confirms a link between tympanosclerosis and atherosclerosis.
  • This is the first report suggesting an association in preclinical atherosclerotic conditions.