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Updated: Jun 10, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[BRNO Register 2: post-myocardial infarction pharmacotherapy]
1Interní kardiologická klinika Lékarské fakulty MU a FN Brno. jspinar@fnbrno.cz
Insights
This study of 850 myocardial infarction patients found high guideline adherence for cardiovascular medications. However, optimal dosing of ACE inhibitors and statins was not consistently achieved, impacting patient outcomes.
Area of Science:
- Cardiology
- Pharmacotherapy
- Public Health
Context:
- Assessed 850 patients with prior myocardial infarction (MI) history at Faculty Hospital Brno.
- Cohort predominantly male (650 vs. 200) and under 70 years old (576 vs. 264).
- Mean age at first MI: 59.0 years (men) vs. 65.5 years (women).
Purpose:
- To evaluate pharmacotherapeutic adherence and clinical outcomes in post-myocardial infarction patients.
- To identify potential gaps in guideline-directed medical therapy.
- To analyze demographic and clinical characteristics influencing treatment.
Summary:
- 75.8% received all guideline-recommended drug classes (RAAS blockers, beta-blockers, statins, antiplatelets).
- Individual drug class use exceeded 90%, with no significant gender or age disparities.
- Suboptimal dosing of ACE inhibitors and statins noted; Perindopril and Atorvastatin were most common.
Impact:
- Identified high overall medication class prescription rates post-MI.
- Highlighted need for optimizing medication dosages for improved cardiovascular risk management.
- Provided insights into patient profiles and treatment patterns in a real-world clinical setting.
Abstract:
We assessed 850 patients with a history of myocardial infarction >1 month ago who attended outpatient clinics of the Clinic of Internal Medicine and Cardiology at the Faculty Hospital Brno between 1st September 2009 and 31st December 2009. There were more men (650 vs. 200) and patients under 70 years of age (576 vs. 264) in the cohort. 87.8% of patients experienced one myocardial infarction only and the mean age at the first infarction was 59.0 years in men and 65.5 in women (p < 0.001). 75.8% of patients had been prescribed all recommended pharmacotherapeutic groups according to guidelines (RAAS blockers, beta-blockers, statins, antiagregation agents) and each group individually was used in > 90% of patients. There were no differences between men and women and older and younger patients. ACE inhibitors and statins were not always prescribed in recommended (high) doses. Perindopril was the most frequently prescribed ACE inhibitor and atorvastatin the most frequently prescribed statin. Blood pressure of< 140/90 mm Hg was identified in 60.1% of patients, 75% of men and 65% of women had cholesterol level of <5 mmol/l and > 50% of patients had cholesterol < or = 4.5 mmol/l, metabolic syndrome was found in about 1/2 of patients and smoking was admitted by 12.5% of patients.
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