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Pd-catalyzed enantioselective allyl-allyl cross-coupling

Ping Zhang1, Laura A Brozek, James P Morken

  • 1Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

Journal of the American Chemical Society
|August 5, 2010
PubMed
Summary

This study details a palladium-catalyzed cross-coupling reaction between allylic carbonates and allylboronates. Ligand bite angle controls regioselectivity, favoring branched products, and chiral ligands enable enantioselective synthesis of allylic substitution products.

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