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Effect of a highly selective central CCK-B receptor agonist: BC-264 on rat sleep
Z de Saint Hilaire1, B P Roques, S Nicolaïdis
1Neurobiologie des Régulations, CNRS UA 637, Collège de France, Paris.
Abstract:
The possible involvement of the CCK-B receptor type in the atypical somnolence and EEG changes induced by low doses of CCK-B was investigated by intraperitoneal administration of three different doses (8, 16 and 32 micrograms/kg) of the new highly potent and selective CCK-B agonist, BC-264, on sleep parameters in the fasted rat. At the dose of 8 micrograms/kg BC-264 induced a significant increase in waking in the second 120 min of recording without effect on slow wave sleep (SWS). BC-264 did not modify the others sleep parameters. Taken all together these results suggest that CCK-B type receptors are probably not critically involved in satiety and sleep.