Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging Learning in Medicine and Citizenship During the COVID-19 Pandemic: A Telehealth-Based Case Study.

JMIR public health and surveillance·2021
Same author

Agreement between three perioperative risk scores.

Revista da Associacao Medica Brasileira (1992)·2016
Same author

[Neurolitic block of the lumbar sympathetic chain improves chronic pain in a patient with critical lower limb ischemia].

Brazilian journal of anesthesiology (Elsevier)·2016
Same author

Methicillin-resistant and methicillin-susceptible community-acquired Staphylococcus aureus infection among children.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2013
Same author

Topical analgesics.

Revista brasileira de anestesiologia·2012
Same author

Sedation with sufentanil and clonidine in patients undergoing heart catheterization.

Arquivos brasileiros de cardiologia·2011

Related Experiment Video

Updated: Jun 10, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Osteogenesis imperfecta in pregnancy. Case report.

Ticiana Goyanna Lyra1, Vanessa Alves Fernandes Pinto, Fábio André Barbosa Ivo

  • 1Maternidade de Referência Professor José Maria de Magalhães Netto, CET/SBA of the Santa Casa de Misericórdia da Bahia, Salvador, BA. ticig@yahoo.com.br

Revista Brasileira De Anestesiologia
|August 5, 2010
PubMed
Summary

This case report highlights a rare pregnancy with Osteogenesis Imperfecta (OI), a brittle bone condition. The successful cesarean delivery and recovery demonstrate effective perioperative management for OI patients.

More Related Videos

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Related Experiment Videos

Last Updated: Jun 10, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

  • Obstetrics and Gynecology
  • Anesthesiology
  • Medical Genetics

Background:

  • Osteogenesis Imperfecta (OI) is a rare genetic disorder characterized by brittle bones.
  • Its prevalence in obstetric patients is significantly lower than in the general population.
  • This report details a unique case of a pregnant woman with mild OI.

Observation:

  • A 23-year-old gravida at 38 weeks presented with ruptured membranes and contractions.
  • The patient had a mild form of Osteogenesis Imperfecta and no prenatal care.
  • Cesarean delivery was performed under spinal anesthesia.

Findings:

  • Pregnancy can be carried to term in women with Osteogenesis Imperfecta, particularly Type I.
  • Surgical delivery is often necessary due to pelvic deformities and potential cephalopelvic disproportion.
  • Spinal anesthesia with bupivacaine and morphine was successfully administered.

Implications:

  • Anesthesiologist's role is crucial in perioperative management for OI patients.
  • Appropriate anesthetic techniques are vital for successful outcomes in OI pregnancies.
  • Fertility is generally preserved in OI patients, allowing for successful term pregnancies.