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Factors associated with complicated buprenorphine inductions
Susan D Whitley1, Nancy L Sohler, Hillary V Kunins
1New York University School of Medicine and Bellevue Hospital Center, New York, NY 10016, USA. susan.whitley@nyumc.org
Journal of Substance Abuse Treatment
|August 5, 2010
Summary
Complicated buprenorphine inductions, marked by withdrawal, occurred in 16.8% of patients. Factors like prior methadone use and low initial doses were linked to these complications, impacting treatment retention.
Area of Science:
- Addiction Medicine
- Pharmacology
- Public Health
Background:
- Buprenorphine is effective for opioid use disorder but faces implementation barriers.
- The induction phase of buprenorphine treatment is critical yet understudied.
- Complications during induction can deter patients from continuing treatment.
Purpose of the Study:
- To identify factors associated with complicated buprenorphine inductions.
- To analyze the impact of complicated inductions on treatment retention.
- To inform strategies for optimizing buprenorphine treatment initiation.
Main Methods:
- Retrospective chart review of 107 patients undergoing buprenorphine treatment.
- Defined complicated induction as precipitated or protracted withdrawal.
- Statistical analysis to identify factors independently associated with complicated inductions.
Main Results:
- 16.8% of patients experienced a complicated induction.
- Complicated inductions were associated with poorer treatment retention.
- Recent methadone/benzodiazepine use, no prior buprenorphine experience, and low initial doses predicted complicated inductions.
Conclusions:
- Complicated buprenorphine inductions are linked to negative treatment outcomes.
- Understanding patient and treatment factors can improve induction success.
- Strategies should address identified risk factors to enhance buprenorphine treatment initiation and retention.
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