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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 10, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

A case study progression to multiple myeloma.

Mary Ann Yancey¹, Adam J Waxman, Ola Landgren

¹Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. yanceym@mail.nih.gov

Clinical Journal of Oncology Nursing

|August 5, 2010

Summary

This summary is machine-generated.

Multiple myeloma develops from precursor states often found incidentally. This case report highlights the challenge of managing progression from precursor to full malignancy, exploring future research in myelomagenesis.

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

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Last Updated: Jun 10, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

Hematology
Oncology
Pathology

Background:

Multiple myeloma is consistently preceded by precursor states.
These precursor conditions are frequently diagnosed incidentally through laboratory findings.

Observation:

This case report details the clinical dilemma encountered during the progression from a precursor state to overt multiple myeloma.
The progression from precursor to full malignancy presents diagnostic and management challenges.

Findings:

The case illustrates the transition from a premalignant condition to active multiple myeloma.
Understanding this progression is key to early intervention.

Implications:

Future management strategies for multiple myeloma should consider precursor states.
Further research into myelomagenesis can inform novel therapeutic approaches and early detection methods.