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Published on: September 25, 2011
MACC1 as a marker for advanced colorectal carcinoma
Atsushi Shirahata1, Kazuki Shinmura, Youhei Kitamura
1Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.
Background:
Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases.
Patients And Methods:
We analyzed MACC1 expression levels in 52 colorectal cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR).
Results:
We found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.042) and higher stage of TNM classification (p=0.007).
Conclusion:
These results suggest that MACC1 is more frequently expressed in advanced colorectal carcinomas.
