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Expression of ki-67 antigen and caspase-3 protein in benign lesions and esophageal carcinoma
Marilanda Ferreira Bellini1, Patrícia Maluf Cury, Ana Elizabete Silva
1IBILCE/UNESP - Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP, Brazil - CEP. 15054-000.
Background:
The present study aimed to evaluate apoptosis and cell proliferation alterations in esophageal benign lesions in comparison to esophageal carcinomas.
Materials And Methods:
Immunohistochemistry was performed for caspase-3 protein (CPP32) and Ki-67 antigen expression in the esophageal mucosa from patients with Chagas disease (CD) with and without megaesophagus (CM), chronic esophagitis (CE), esophageal carcinoma (ESCC) and in normal mucosa (NM).
Results:
The Ki-67 labeling index (LI) was similar in all groups (range: 30%-48%), having no statistically significant difference among the groups. Positive CPP32 immunostaining was observed with similar frequency in the CD (30.8%), CM (30.4%) and CE (34.8%) groups, but it was increased in the ESCC group (55.5%); however, it was not statistically different from the other groups. No associations among the levels of CPP32 and Ki-67 expression were observed in the various groups, neither among parameters such as age, gender or alcohol and tobacco consumption.
Conclusion:
There were no evident changes in cell proliferation and apoptosis in benign lesions studied.
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