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Related Experiment Video

Updated: Jun 10, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Triglyceride lipases and atherosclerosis.

Gunilla Olivecrona¹, Thomas Olivecrona

¹Department of Medical Biosciences, Section on Physiological Chemistry, Umeå University, Umeå, Sweden. gunilla.olivecrona@medbio.umu.se

Current Opinion in Lipidology

|August 5, 2010

Summary

Lipoprotein lipase (LPL) system derangements contribute to atherosclerosis. Understanding LPL

Area of Science:

Lipid metabolism
Atherosclerosis research
Enzyme function in cardiovascular disease

Background:

Strong epidemiological links exist between plasma triglycerides and atherosclerosis.
The role of the lipoprotein lipase (LPL) system in this association requires further elucidation.
Hepatic lipase and endothelial lipase also play roles in lipoprotein metabolism.

Purpose of the Study:

To investigate the extent to which derangements in the lipoprotein lipase (LPL) system contribute to atherosclerosis.
To review the roles of hepatic lipase and endothelial lipase in this context.

Main Methods:

Review of recent findings on LPL system components and their functions.
Analysis of genetic variant studies related to lipase activity.

Related Experiment Videos

Last Updated: Jun 10, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Examination of the physiological regulation of lipase activity.

Main Results:

Discovery of lipase maturation factor 1 and glycosylphosphatidylinositol-anchored HDL-binding protein 1 advances understanding of LPL function.
Angiopoietin-like proteins modulate LPL activity.
Genetic studies confirm the critical roles of lipases in lipoprotein metabolism and atherosclerosis.

Conclusions:

Derangements in lipases contribute to atherogenesis through various mechanisms.
Lipase activity significantly influences plasma lipoprotein profiles.
Efficient removal of lipase-generated fatty acids and monoglycerides is crucial for endothelial integrity and preventing lipotoxicity.