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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

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Related Experiment Video

Updated: Jun 10, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Cardiac involvement in patients with hematologic malignancies.

Alessandro Allegra1, Andrea Alonci, Sabina Russo

  • 1Division of Hematology, University of Messina, Messina, Italy.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|August 5, 2010
PubMed
Summary

Hematologic cancers and their treatments can cause heart problems. This review covers cardiac issues from leukemia, lymphoma, and myeloma, focusing on new drug toxicities and potential regenerative therapies.

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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Published on: January 21, 2018

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Area of Science:

  • Cardio-oncology
  • Hematology
  • Internal Medicine

Background:

  • Cardiologic diseases frequently arise secondary to hematologic pathologies or their treatments.
  • Myocardial infiltration is a key concern in hematologic malignancies like leukemia, lymphoma, multiple myeloma, and hypereosinophilic syndrome.

Purpose of the Study:

  • To review the management of cardiac disease in patients with hematologic pathology.
  • To evaluate chemotherapy-associated cardiac toxicity, especially from novel therapeutic agents.
  • To discuss early cardiac injury markers and regenerative cardiac stem cell therapy.

Main Methods:

  • Comprehensive literature review focusing on cardiac complications in hematologic diseases.
  • Analysis of cardiotoxicity associated with conventional and novel cancer therapies.
  • Exploration of diagnostic markers and therapeutic strategies for cardiac regeneration.

Main Results:

  • Cardiac toxicity from hematologic therapies can manifest as asymptomatic changes or life-threatening events.
  • Novel agents like monoclonal antibodies, tyrosine kinase inhibitors, arsenic trioxide, bortezomib, and epigenetic therapies pose specific cardiac risks.
  • Cardiotoxicity may necessitate treatment modification, including dose reduction, delays, or discontinuation.

Conclusions:

  • Early identification of cardiac injury markers is crucial for timely intervention.
  • Cardiac stem cell therapy presents a promising avenue for myocardial regeneration in affected patients.
  • Multidisciplinary management is essential for patients with hematologic malignancies and secondary cardiac conditions.