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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

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Related Experiment Video

Updated: Jun 10, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Disuse-related decline in trabecular bone structure.

M P Akhter1, G K Alvarez, D M Cullen

  • 1ORC, Creighton University, Suite 4820, 610 N, 30th Street, Omaha, NE 68131, USA. akhtermp@creighton.edu

Biomechanics and Modeling in Mechanobiology
|August 5, 2010
PubMed
Summary
This summary is machine-generated.

The LRP5 G171V mutation offers protection against disuse-related bone loss, significantly reducing bone degradation in mice subjected to hindlimb suspension. This high bone mass (HBM) mutation preserves bone structure better than wild-type or LRP5-knockout models.

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Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
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09:36

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

Area of Science:

  • Bone Biology
  • Skeletal Physiology
  • Genetics of Bone Disease

Background:

  • Sedentary lifestyles contribute to bone mass degradation and osteoporosis.
  • The LRP5 gene plays a crucial role in bone development and regulation.
  • Understanding genetic factors that protect against bone loss is vital for osteoporosis prevention.

Purpose of the Study:

  • To investigate the protective effects of the LRP5 G171V mutation against disuse-related bone loss.
  • To characterize changes in trabecular bone structure under conditions of disuse in mice with different LRP5 genotypes.
  • To compare the relative bone loss between wild-type, LRP5-knockout, and high bone mass (HBM) mice.

Main Methods:

  • Utilized a hindlimb suspension model in adult male mice over 4 weeks.
  • Compared three genotypes: wild-type (WT), LRP5-knockout (+/-), and high bone mass (HBM) with the LRP5 G171V mutation.
  • Analyzed trabecular bone structural properties including bone volume fraction (BV/TV), thickness, number, connectivity density, and separation.

Main Results:

  • Disuse led to a decline in trabecular bone volume fraction (BV/TV) across all genotypes.
  • The HBM and LRP5 (+/-) KO disuse groups showed lower trabecular thickness compared to controls.
  • Relative bone loss was significantly greater in LRP5 (+/-) mice (67%) than in HBM mice (14%) due to disuse.

Conclusions:

  • The LRP5 G171V mutation confers significant protection against disuse-induced bone structural degradation.
  • While disuse impacts bone structure in all genotypes, the HBM mutation mitigates the severity of bone loss.
  • These findings highlight the potential of targeting LRP5 pathways for therapeutic interventions against osteoporosis.