Related Experiment Video
Updated: Jun 10, 2026
09:37
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases
Sue Povey1, Aida I Al Aqeel, Anne Cambon-Thomsen
1Department of Genetics, Evolution and Environment, University College London, London, United Kingdom. s.povey@ucl.ac.uk
Human Mutation
|August 5, 2010
Summary
New ethical guidelines address sharing genetic variation data from locus-specific databases (LSDBs). These guidelines aim to facilitate global data access for managing genetic disorders while respecting privacy and ethical considerations.
Area of Science:
- Genetics
- Bioethics
- Bioinformatics
Background:
- Over 1,000 locus-specific variation databases (LSDBs) exist, linking phenotype to genotype.
- Unpublished genetic data in diagnostic labs could aid genetic disorder management.
- Sharing this data globally presents significant ethical challenges.
Related Concept Videos
02:26Comparing Copy Number Variations and SNPs
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
01:56Ethics in Research
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
01:16Cell Lines
A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
01:27Ethical Issues
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
Ethical Concerns in Healthcare: