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Cochlear hydrops analysis masking procedure results in patients with unilateral Ménière's disease
Charlotte M Kingma1, Hero P Wit
1Department of Otolaryngology, University Medical Center Groningen, Groningen, The Netherlands.
Objective:
To investigate the usefulness of the cochlear hydrops analysis masking procedure (CHAMP) as an additional diagnostic test in patients with definite unilateral Ménière's disease.
Study Design:
Prospective validation study for a diagnostic test.
Setting:
Tertiary referral center.
Patients:
Subjects (n = 22) with definite unilateral Ménière's disease.
Interventions:
The CHAMP test was performed in both ears of the patients.
Main Outcome Measure:
Difference in latency delay between the affected and the unaffected ears.
Results:
In 20 subjects, latency delays could be measured in both ears. The mean latency delay for the affected ears (0.55 ms; standard error, 0.12 ms) differs significantly from that for the unaffected ears (3.36 ms; standard error, 0.43 ms). With the standard criterion to separate ears with an abnormally short delay (<0.3 ms) from ears with a normal delay, in only 7 of 20 affected ears, an abnormally short delay was measured. All 33 other ears produced a normal delay. With the less than 0.3 ms criterion and including the ears in which no delay could be measured, the sensitivity of the CHAMP is 32% (7/22). Pooling CHAMP latency delays for 235 ears from this work and the literature yielded 2 clearly distinct distributions, with a separation at 2 ms. Defining abnormal delays as shorter than 2 ms gave an abnormal delay for 18 of 20 affected ears and for 7 of 20 unaffected ears.
Conclusion:
Abnormal latency delays for CHAMP are delays shorter than 2 ms. Earlier results with CHAMP should be reconsidered using this criterion, instead of 0.3 ms.
